Aggresome - CISMeF

Preferred Label : Aggresome;

NCIt definition : A ubiquitin-rich cytoplasmic inclusion encased in vimentin found near the microtubule organizing center. It is formed in response to cellular stresses that cause the production of misfolded proteins at levels that exceed the degradative capacity of the proteasome. This inclusion body is comprised of aggregated misfolded or denatured proteins that have been transported along microtubules to the pericentriolar space where they become encased in vimentin.;

Details

Origin ID

C118897;

UMLS CUI

C1167059;

Anatomic structure is physical part of
- Cell [NCIt concept]
- Cytoplasm [NCIt concept]
Currated CISMeF NLP mapping
- aggresome [GO term]
Semantic type(s)
- Cell Component [UMLS semantic type]
UMLS correspondences (same concept)
- aggresome [GO term]
anatomic_structure_has_location
- Centrosome [NCIt concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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