" /> Autologous IL-2-expressing B-CLL Vaccine - CISMeF





Preferred Label : Autologous IL-2-expressing B-CLL Vaccine;

NCIt synonyms : Autologous IL2-transduced CLL B Cell Vaccine;

NCIt definition : A cancer vaccine consisting of autologous, B-chronic lymphocytic leukemia (B-CLL) cells harvested from a patient and transduced ex vivo with an adenoviral vector encoding the gene for the human cytokine interleukin-2 (IL-2), with potential immunostimulating and antineoplastic activities. Upon reintroduction into the patient, the autologous IL-2-expressing B-CLL vaccine expresses IL-2, stimulates natural killer (NK) cells, and may enhance the cytotoxic T-lymphocyte (CTL) immune response against the patient's B-CLL cells.;

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30/07/2025


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