Penclomedine - CISMeF

Preferred Label : Penclomedine;

NCIt synonyms : 3,5-dichloro-2,4-dimethoxy-6-(trichloromethyl) pyridine; PEN;

NCIt related terms : Pyridine, 3,5-dichloro-2,4-dimethoxy-6-(trichloromethyl)-;

NCIt definition : A synthetic derivative of pyrimidine with antineoplastic activity. Penclomedine alkylates and crosslinks DNA, resulting in DNA strand breaks and inhibition of DNA and RNA synthesis. This agent is more active against tumor cells that are defective in p53 function. (NCI04);

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called alkylating agents.;

UNII : 66Q80IL7CW;

InChIKey : DZVPGIORVGSQMC-UHFFFAOYSA-N;

CAS number : 108030-77-9;

Molecule name : CRC 88-04;

Chemical formula : C8H6Cl5NO2;

NSC code : 338720;

Codes from synonyms : NSC0338720; CDR0000045411;

Details

Origin ID

C1188;

UMLS CUI

C0070220;

Currated CISMeF NLP mapping
- penclomedine [MeSH concept]
- penclomedine [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- penclomedine [MeSH Supplementary Concept]
- penclomedine [MeSH concept]
chemical_or_drug_has_mechanism_of_action
- DNA Alkylation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Base Pair Miscoding [NCIt concept]
- DNA Crosslinking [NCIt concept]
- DNA Synthesis Inhibition [NCIt concept]
- RNA Transcription Inhibition [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Filgrastim/Penclomedine [NCIt concept]

Keyword's position in hierarchy(ies) :

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