Preferred Label : Ingenol Mebutate Gel;
NCIt synonyms : Ingenol-3-angelate Gel;
NCIt definition : A topical, aqueous gel formulation containing the mebutate salt form of ingenol, a
selective small-molecule activator of protein kinase C (PKC) that is isolated from
the sap of Euphorbia species, with potential antineoplastic activity. Upon topical
application of the ingenol mebutate gel, ingenol activates various PKC isoforms, which
induces apoptosis in certain tumor cells, including myeloid leukemia cells, melanoma
cells, and basal cell carcinoma cells. The PKC family consists of signaling isoenzymes
that regulate many cell processes, including proliferation, differentiation, and apoptosis.;
Drug name : Picato;
Molecule name : PEP-005 Topical Gel; PEP005 Gel;
Origin ID : C118776;
UMLS CUI : C3898761;
Semantic type(s)
- concept_is_in_subset
