Preferred Label : Abivertinib Maleate Anhydrous;
NCIt synonyms : AC0010 Maleate; AC0010 Maleate Dihydrate; Avitinib Maleate;
NCIt definition : The maleate salt form of abivertinib, an orally available, irreversible, epidermal
growth factor receptor (EGFR) mutant-selective inhibitor, with potential antineoplastic
activity. Upon oral administration, abivertinib covalently binds to and inhibits the
activity of mutant forms of EGFR, including the drug-resistant T790M EGFR mutant,
which prevents signaling mediated by mutant forms of EGFR. This may both induce cell
death and inhibit tumor growth in EGFR-mutated tumor cells. EGFR, a receptor tyrosine
kinase that is mutated in a variety of cancers, plays a key role in tumor cell proliferation
and tumor vascularization. As this agent is selective towards mutant forms of EGFR,
its toxicity profile may be reduced when compared to non-selective EGFR inhibitors,
which also inhibit wild-type EGFR.;
UNII : 0447KM2XTD;
CAS number : 1557268-88-8;
Molecule name : AC0010MA; STI-5656;
Origin ID : C118671;
UMLS CUI : C3899984;
Semantic type(s)
- concept_is_in_subset
- has_target
