Preferred Label : Rhenium Re 188 BMEDA-labeled Liposomes;
NCIt synonyms : (188) Re-BMEDA-liposomes; 188Re-N,N-bis (2-Mercaptoethyl)-N',N'-diethylethylenediamine-labeled Liposomes; 188Re-BMEDA-liposomes;
NCIt definition : A liposome-based preparation consisting of the beta- and gamma-emitting radionuclide
rhenium Re 188 (Re 188) linked to the chelator N,N-bis (2-mercaptoethyl)-N',N'-diethylethylenediamine
(BMEDA) and encapsulated in liposomes, with potential tumor imaging and antineoplastic
activities. Upon intravenous infusion of rhenium Re 188 BMEDA-labeled liposomes, the
liposomes selectively target tumor cells, facilitate the retention of the radioisotope
by those cells, and cause localized antitumor radiocytotoxicity while sparing surrounding
normal, healthy cells. In addition, Re 188 BMEDA-labeled liposomes can be used for
imaging purposes. Re 188 has a short half-life and a short path length, which further
contribute to limiting the radiotoxicity to the tumor cells.;
Origin ID : C118670;
UMLS CUI : C3897117;
Semantic type(s)
- concept_is_in_subset
