NCIt definition : A nanoparticle-based suspension containing the water-insoluble taxane paclitaxel,
with potential antineoplastic activity. Upon intraperitoneal administration, paclitaxel
binds to tubulin and inhibits the disassembly of microtubules, which leads to the
inhibition of cell division. The nanoparticle-based formulation is devoid of toxic
solvents, such as cremophor; therefore, this agent has fewer side effects than the
standard, solvent-based paclitaxel formulation.;
Semantic type(s)