Preferred Label : Lung-targeted Immunomodulator QBKPN;
NCIt synonyms : SSI QBKPN; Site Specific Immunomodulator QBKPN;
NCIt definition : A proprietary, lung-targeted, site specific immunomodulator (SSI), with potential
immunostimulating and antineoplastic activities. Although the exact type and composition
of the lung-targeted immunomodulator QBKPN has yet to be fully disclosed, upon subcutaneous
administration, this agent is able to activate a local innate immune response in the
lung tissue. This results in an increased number of M1 macrophages, which induces
a shift from M2 to M1 macrophage dominance in the tumor microenvironment, and stimulates
the recruitment of other immune cells. The M1 macrophages exert antitumor activity
and eradicate lung cancer cells through phagocytosis. QBKPN does not induce a systemic
immune response or affect other organs or tissues. Altogether, this SSI may decrease
tumor cell growth in the lungs. SSIs contain specific, inactivated components of pathogens,
such as bacteria and/or viruses, which normally cause an acute infection in the specific
organ or tissue of interest.;
Molecule name : QBKPN;
Origin ID : C118623;
UMLS CUI : C3896726;
Semantic type(s)
- concept_is_in_subset
