PCNU - CISMeF

Preferred Label : PCNU;

NCIt synonyms : 1-(2-Chloroethyl)-3-(2,6-Dioxo-3-Piperidyl)-1-Nitrourea; Urea, N-(2-chloroethyl)-N'-(2,6-dioxo-3-piperidinyl)-N-nitroso-;

NCIt related terms : 1-(2-CHLOROETHYL)-3-(2,6-DIOXO-3-PIPERIDYL)-1-NITROSOUREA;

NCIt definition : A chloroethylnitrosourea compound and an alkylating agent with antineoplastic property. PCNU inhibits DNA synthesis by alkylating DNA and causing DNA cross links, thereby inducing apoptosis. In addition, this agent may be associated with pulmonary, hepatic, and hematologic toxicities. Unlike other nitrosoureas, PCNU has strong alkylating while weak carbamoylating activity.;

UNII : AZW59V4Q3B;

CAS number : 13909-02-9;

NSC code : 95466;

Codes from synonyms : NSC0095466;

Details

Origin ID

C1186;

UMLS CUI

C0070165;

Currated CISMeF NLP mapping
- 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidinyl)-1-nitrosourea [MeSH concept]
- 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidinyl)-1-nitrosourea [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidinyl)-1-nitrosourea [MeSH concept]
- 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidinyl)-1-nitrosourea [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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