Preferred Label : Plectin-1 Targeting Agent PTP-01;
NCIt definition : An imaging agent containing a plectin-1 (Plec1; plectin) targeting peptide (PTP),
with potential use for the detection of Plec1-expressing tumor cells using single-photon
emission computed tomography (SPECT). Upon administration, the Plec1 targeting agent
PTP-01 specifically targets and binds to Plec1 on Plec1-expressing cancer cells. Upon
SPECT imaging, the Plec1-expressing cancer cells can be visualized. Plec1, a pro-tumorigenic
protein, is normally found inside the cytoplasm of healthy cells but is only selectively
expressed on the cell surface of various cancer cells and plays an important role
in cancer cell proliferation, migration and invasion.;
Molecule name : PTP-01;
NCI Metathesaurus CUI : CL471753;
Origin ID : C118575;
UMLS CUI : C3896782;
Semantic type(s)
- concept_is_in_subset
- has_target
