Preferred Label : Artemether Sublingual Spray;
NCIt synonyms : Sublingual Artemether Spray;
NCIt definition : A sublingual spray containing artemether, a semisynthetic derivative of artemisinin,
an endoperoxide extracted from the Chinese herb qinghaosu (Artemisia annua or annual
wormwood), with antiparasitic and potential antineoplastic activity. Upon sublingual
application of the spray, artemether exerts its antineoplastic activity through as
of yet not fully elucidated mechanism(s) of action. This agent binds to heme molecules
inside cells, thereby inducing reactive oxygen species (ROS)-mediated damage which
selectively kills cancer cells. In addition, artemether appears to target and modulate
the expression of various proteins involved in cancer cell proliferation, angiogenesis,
invasion and metastasis. Also, this agent depletes T regulatory cells, and modulates
the production of inflammatory cytokines, such as interleukin-4 and interferon-gamma.
Altogether, this inhibits tumor cell proliferation. The sublingual spray allows faster
absorption of a higher percentage of the artemether dose, when compared to the oral
form, as it avoids first pass metabolism; this results in an increased efficacy.;
Molecule name : LON002;
Origin ID : C118504;
UMLS CUI : C3900015;
Semantic type(s)
- concept_is_in_subset
