Preferred Label : Copper Cu 64 Anti-CEA Monoclonal Antibody M5A;
NCIt synonyms : Cu 64-M5A; 64Cu-DOTA-M5A;
NCIt definition : A radioimmunoconjugate consisting of a humanized monoclonal antibody directed against
the human carcinoembryonic antigen, carcinoembryonic antigen-related cell adhesion
molecule 5 (CEA or CEACAM5), which is conjugated with the radioisotope copper Cu 64
via the chelator tetra-azacyclododecanetetra-acetic acid (DOTA), with potential use
as an imaging agent during positron emission tomography (PET). Upon administration,
the antibody moiety of copper Cu 64 anti-CEA monoclonal antibody M5A specifically
binds to cells expressing CEA. Upon binding, the radioisotope moiety can be detected
using PET, thereby allowing the imaging and quantification of CEA-expressing tumor
cells. CEA, a tumor associated antigen and a member of the CEA family of proteins,
plays a key role in cell migration, cell invasion, and cell adhesion and is overexpressed
by a variety of cancer types.;
Origin ID : C118454;
UMLS CUI : C3899498;
Semantic type(s)
- concept_is_in_subset
- has_target
