NCIt definition : A genetically engineered epothilone analog with potential antineoplastic activity.
Upon administration, utidelone binds to tubulin, induces microtubule polymerization
and stabilizes microtubules against depolymerization, which may result in the inhibition
of cell division, the induction of G2/M arrest, and apoptosis. Compared to first-generation
epothilones, this agent exhibits greater safety and enhanced activity against certain
multidrug-resistant (MDR) tumors.;
Semantic type(s)