Preferred Label : Gemigliptin;
NCIt synonyms : 1-((2S)-2-Amino-4-(2,4-bis(trifluoromethyl)-5,8-dihydropyrido(3,4-d)pyrimidin-7(6H)-yl)-4-oxobutyl-5,5-difluoropiperidin-2-one;
NCIt definition : An orally bioavailable inhibitor of the serine protease dipeptidyl peptidase 4 (DPP-4),
with hypoglycemic and potential renoprotective activities. Upon administration, gemigliptin
binds to DPP-4 and inhibits the breakdown of the incretin hormones, glucagon-like
peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). This prolongs
incretin activity, increases postprandial insulin secretion from pancreatic beta cells,
decreases glucagon secretion, delays gastric emptying and lowers blood glucose levels.
In addition, gemigliptin exerts a renoprotective effect, probably through enhanced
GLP-1 signaling, may prevent apoptosis and acute kidney injury induced by nephrotoxic
agents, and may protect against diabetic nephropathy.;
UNII : 5DHU18M5D6;
InChIKey : ZWPRRQZNBDYKLH-VIFPVBQESA-N;
CAS number : 911637-19-9;
Molecule name : LC15-0444;
Origin ID : C118446;
UMLS CUI : C3501981;
Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
