NCIt definition : A monoclonal antibody directed against the ganglioside fucosyl-GM1, with potential
antineoplastic and immunomodulating activities. Upon administration, anti-fucosyl-GM1
monoclonal antibody BMS-986012 binds to fucosyl-GM1 on cancer cells and may activate
both antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity
against the bound tumor cells. This may inhibit the proliferation of GM1-expressing
tumor cells. Fucosyl-GM1, a sphingolipid monosialoganglioside and tumor associated
antigen (TAA), is overexpressed on the surface of many cancer cells while its expression
is minimal or non-existent in normal tissues.;
UNII : Q8PK97HY9B;
CAS number : 1894272-37-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1894272-37-7
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G-SRS /a ;
Semantic type(s)