NCIt definition : A monoclonal antibody directed against the ganglioside fucosyl-GM1, with potential
antineoplastic and immunomodulating activities. Upon administration, atigotatug binds
to fucosyl-GM1 on cancer cells and may activate both antibody-dependent cellular cytotoxicity
(ADCC) and complement-dependent cytotoxicity against the bound tumor cells. This may
inhibit the proliferation of GM1-expressing tumor cells. Fucosyl-GM1, a sphingolipid
monosialoganglioside and tumor associated antigen (TAA), is overexpressed on the surface
of many cancer cells while its expression is minimal or non-existent in normal tissues.;
Semantic type(s)