NCIt synonyms : Humanized gpA33 x CD3 DART (TM) Protein MGD007;
NCIt related terms : MGD-007;
NCIt definition : An anti-glycoprotein A33 (gpA33)/anti-CD3 bispecific humanized monoclonal antibody
with potential immunostimulatory and antineoplastic activities. Anti-gpA33/CD3 monoclonal
antibody MGD007 possesses two antigen-recognition sites, one for the CD3 complex,
a group of T-cell surface glycoproteins that complex with the T-cell receptor (TCR),
and one for gpA33, a tumor-associated antigen (TAA) overexpressed on the surface of
certain tumor cells. Upon administration of MGD007, this bispecific antibody simultaneously
binds to both CD3-expressing T-cells and gpA33-expressing cancer cells, thereby crosslinking
cytotoxic T-lymphocytes (CTLs) to gpA33-expressing tumor cells. This may result in
CTL-mediated cell lysis of the crosslinked tumor cells. The gpA33 antigen, a member
of the immunoglobulin superfamily, is expressed in certain malignancies, including
colon and gastrointestinal cancers.;
Semantic type(s)