NCIt synonyms : Lendalizumab; Immunoglobulin, Anti-(human complement C5a) (human-mus musculus ALXN1007 heavy chain),
Disulfide with Human-mus Musculus ALXN1007 Kappa-chain, Dimer;
NCIt definition : A humanized monoclonal antibody directed against the complement protein C5a, with
potential immunomodulating and anti-inflammatory activities. Upon administration,
olendalizumab targets and binds to C5a. This prevents the binding of C5a to its receptor
C5a receptor (C5aR) and prevents C5a/C5aR-mediated pro-inflammatory signaling, thereby
reducing inflammation and tissue and organ damage. C5a, a factor in the complement
cascade, plays important roles in inflammation and immunity.;
Currated CISMeF NLP mapping