Protransforming Growth Factor Alpha

Preferred Label : Protransforming Growth Factor Alpha;

NCIt synonyms : Pro-Transforming Growth Factor Alpha;

NCIt definition : Protransforming growth factor alpha (160 aa, 17 kDa) is encoded by the human TGFA gene. This protein plays a role in cell proliferation.;

NCIt note : The active form of the growth factor, transforming growth factor alpha, is produced when proteolytic cleavage removes 39 amino acids from the N-terminus and 71 amino acids from the C-terminus of protransforming growth factor alpha. The precursor is a transmembrane protein and the mature form is a secreted protein. (UniProt);

Details

Origin ID

C118440;

UMLS CUI

C0072502;

Automatic exact mappings (from CISMeF team)
- protransforming growth factor alpha [MeSH Supplementary Concept]
- protransforming growth factor alpha [MeSH concept]
- transforming growth factor alpha [MeSH Descriptor]
OMIM relation
- Transforming growth factor, alpha [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- protransforming growth factor alpha [MeSH Supplementary Concept]
- protransforming growth factor alpha [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Growth Factor Gene [NCIt concept]
- TGFA Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Transforming Growth Factor [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation Regulatory Process [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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