" /> KRAS Activating Mutation - CISMeF





Preferred Label : KRAS Activating Mutation;

NCIt synonyms : c-K-ras Activating Mutation; KRAS2 Activating Mutation; KRAS-2 Activating Mutation; v-Ki-ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog Activating Mutation; Activating KRAS Mutation; KRAS Proto-Oncogene, GTPase Activating Mutation;

NCIt definition : A change in the nucleotide sequence of the KRAS gene that that results in constitutive signal transduction, which stimulates downstream signaling pathways involved in cell growth, proliferation, invasion, and metastasis. The presence of KRAS activating mutations in colorectal cancer and non-small-cell lung cancer is used identify the subgroup of patients who are most likely to respond to EGFR antagonist chemotherapy.;

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10/05/2025


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