Preferred Label : Polaprezinc;
NCIt synonyms : Zinc, (beta-alanyl-kappaN-L-histidinato(2-)-kappaN,kappaO)-; Carnosine Zinc Complex; Aprozinate; Zinc L-carnosine;
NCIt definition : An orally bioavailable chelate composed of zinc and L-carnosine, with potential gastroprotective,
anti-oxidant, anti-ulcer and anti-inflammatory activities. Upon administration, polaprezinc
increases the expression of various anti-oxidant enzymes, such as superoxide dismutase
1 (SOD-1), SOD-2, heme oxygenase-1 (HO-1), glutathione S-transferase (GST), glutathione
peroxidase (GSH-px), peroxidredoxin-1 (PRDX1; PRXI) and PRXD5 (PRXV) in the gastric
mucosa, which protect cells against reactive oxygen species (ROS). In addition, this
agent inhibits the activity of the transcription factor nuclear factor-kappaB (NF-kappaB)
and reduces the expression of several pro-inflammatory cytokines, such as interleukin
(IL) 1beta, IL-6, IL-8, and tumor necrosis factor alpha (TNF-a). Polaprezinc also
increases the expression of various growth factors, such as platelet-derived growth
factor-B (PDGF-B), vascular endothelial growth factor (VEGF), and nerve growth factor
(NGF), and various heat shock proteins (HSPs), including HSP90, HSP70, HSP60, HSP47,
HSP27, and HSP10. This protects against damages to, and accelerates healing of the
gastric mucosa.;
UNII : 0WA1B15A1Z;
InChIKey : IGXZLYMCFZHNKW-FJXQXJEOSA-L;
CAS number : 107667-60-7;
Molecule name : Z 103;
Origin ID : C118371;
UMLS CUI : C0286382;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
