Ranpirnase - CISMeF

Preferred Label : Ranpirnase;

NCIt synonyms : P-30 Protein; P-30; P30; P30 Protein;

NCIt related terms : Onconase;

NCIt definition : A natural homologue of ribonuclease A isolated from the eggs of the frog Rana pipiens. Ranpirnase primarily degrades cellular transfer RNA with a substrate specificity for uridine-guanidine base-pair sequences, resulting in inhibition of protein synthesis and cytotoxicity. This agent also activates caspase-9 in mitochondria, resulting in tumor cell apoptosis. (NCI04);

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It is a type of ribonuclease enzyme.;

UNII : ZE15FIT23E;

CAS number : 196488-72-9;

Drug name : Onconase;

Codes from synonyms : 30976; CDR0000335503; CDR0000045356;

Details

Origin ID

C1183;

UMLS CUI

C0069919;

Currated CISMeF NLP mapping
- ranpirnase [MeSH concept]
- ranpirnase [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ranpirnase [MeSH concept]
- ranpirnase [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Doxorubicin/P-30 Protein [NCIt concept]
- Doxorubicin/Ranpirnase [NCIt concept]
- P-30 Protein/Tamoxifen [NCIt concept]
- Ranpirnase/Tamoxifen [NCIt concept]

Keyword's position in hierarchy(ies) :

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