NCIt definition : A radioimmunoconjugate comprised of the recombinant chimeric monoclonal antibody girentuximab,
that binds an extracellular epitope of carbonic anhydrase IX (CAIX), and labeled with
the radioisotope zirconium 89 (Zr 89) with potential use as an imaging agent upon
positron emission tomography (PET). The antibody moiety of zirconium Zr 89 girentuximab
binds to CAIX expressed on tumor cells. Upon binding, the radioisotope moiety may
be detected using PET, which enables the imaging and quantification of CAIX-expressing
tumor cells. CAIX, a hypoxia-inducible transmembrane glycoprotein, is overexpressed
on renal cell carcinoma (RCC) and various other tumors; it plays a key role in intra-
and extracellular pH regulation, cancer cell progression, survival, migration and
invasion.;
CISMeF manual mappings