Preferred Label : Altiratinib;
NCIt synonyms : 1,1-Cyclopropanedicarboxamide, N-(4-((2-((cyclopropylcarbonyl)amino)-4-pyridinyl)oxy)-2,5-difluorophenyl)-N'-(4-fluorophenyl)-;
NCIt definition : An orally bioavailable inhibitor of c-Met/hepatocyte growth factor receptor (HGFR),
vascular endothelial growth factor receptor type 2 (VEGFR2), Tie2 receptor tyrosine
kinase (TIE2), and tropomyosin receptor kinase (Trk), with potential antiangiogenic
and antineoplastic activities. Upon administration, altiratinib selectively binds
to c-Met, VEGFR2, Tie2 and Trk tyrosine kinases, which may lead to the inhibition
of endothelial cell migration, proliferation and survival. This also results in both
an inhibition of tumor cell proliferation and increased tumor cell death in c-Met/VEGFR2/Tie2/Trk-expressing
cells. These receptor tyrosine kinases (RTKs), frequently overexpressed or mutated
by a variety of tumor cell types, play crucial roles in the regulation of angiogenesis,
tumor cell growth and survival.;
UNII : T678746713;
InChIKey : GNNDEPIMDAZHRQ-UHFFFAOYSA-N;
CAS number : 1345847-93-9;
Molecule name : DCC-2701;
Origin ID : C118290;
UMLS CUI : C3900055;
Semantic type(s)
- concept_is_in_subset
