Preferred Label : Oral Azacitidine;
NCIt related terms : Azacitidine oral;
NCIt definition : An orally bioavailable formulation of azacitidine, a pyrimidine nucleoside analogue
of cytidine, with antineoplastic activity. Upon oral administration, azacitidine is
taken up by cells and metabolized to 5-azadeoxycitidine triphosphate. The incorporation
of 5-azadeoxycitidine triphosphate into DNA reversibly inhibits DNA methyltransferase,
and blocks DNA methylation. Hypomethylation of DNA by azacitidine may re-activate
tumor suppressor genes previously silenced by hypermethylation, resulting in an antitumor
effect. In addition, the incorporation of 5-azacitidine triphosphate into RNA disrupts
normal RNA function and impairs tRNA (cytosine-5)-methyltransferase activity, resulting
in an inhibition of RNA and protein synthesis.;
Drug name : Onureg;
Molecule name : CC-486; CC 486;
NCI Metathesaurus CUI : CL474140;
Codes from synonyms : 29973;
Origin ID : C118288;
UMLS CUI : C3897088;
Semantic type(s)
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
