Preferred Label : Recombinant Oncostatin M;
NCIt synonyms : OSM; Therapeutic Oncostatin M;
NCIt definition : A recombinant 26.0 kDa protein, containing 227 amino acid residues, a member of the
cytokine family and growth and differentiation factor that participates in the regulation
of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes
and Kaposi's sarcoma cells, oncostatin M (OSM) can exert both stimulatory and inhibitory
effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth
muscle cells and Kaposi's sarcoma cells, but inhibits the growth of some normal and
tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF)
from endothelial cells, and enhances the expression of low-density lipoprotein receptor
in hepatoma cells.;
CAS number : 106956-32-5;
Origin ID : C1180;
UMLS CUI : C3887694;
False automatic mappings
- Semantic type(s)
