Preferred Label : Nelipepimut-S;
NCIt synonyms : Human Receptor Tyrosine-Protein Kinase erbB-2 (Proto-Oncogene Neu, Tyrosine Kinase-
type Cell Surface Receptor HER2, CD340)-(347-355)-Peptide; E75 Peptide; L-Leucine, L-lysyl-L-isoleucyl-L-phenylalanylglycyl-L-seryl-L-leucyl-L-alanyl-L- phenylalanyl-; Nelipepimut S;
NCIt definition : A cancer vaccine comprised of a human leukocyte antigen (HLA) A2/A3 restricted HER2/neu
(human epidermal growth factor receptor 2; ErbB2) nonapeptide derived from the extracellular
domain of the HER2 protein, with potential immunomodulating and antineoplastic activities.
Upon intradermal injection, nelipepimut-S may induce a specific cytotoxic T-lymphocyte
(CTL) response against HER2/neu-expressing tumor cells. HER2/neu, a tumor-associated
antigen and a member of the epidermal growth factor receptor family of tyrosine kinases,
is overexpressed in various tumor cell types and plays a key role in tumorigenesis.;
UNII : 7M0A29CD8B;
CAS number : 160212-35-1;
Drug name : NeuVax;
Origin ID : C117985;
UMLS CUI : C3898150;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
