Preferred Label : Anti c-KIT Antibody-drug Conjugate LOP628;
NCIt synonyms : Anti c-KIT ADC LOP628;
NCIt definition : An antibody-drug conjugate (ADC) consisting of a humanized monoclonal antibody against
the stem cell factor receptor c-Kit (SCFR) and conjugated, via a non-cleavable linker,
to the cytotoxic agent maytansine, with potential antineoplastic activity. The monoclonal
antibody moiety of anti c-KIT ADC LOP628 targets and binds to the cell surface antigen
c-Kit. After antibody-antigen interaction followed by internalization, the maytansine
moiety binds to tubulin, inhibits microtubule assembly, and induces microtubule disassembly.
This leads to a disruption of mitosis and the inhibition of cell proliferation in
cancer cells expressing c-Kit. c-Kit, a transmembrane protein and receptor tyrosine
kinase, is overexpressed in solid tumors and hematological malignancies; it plays
a key role in the regulation of cell differentiation and proliferation.;
Molecule name : LOP628;
NCI Metathesaurus CUI : CL474131;
Origin ID : C117735;
UMLS CUI : C3896824;
Semantic type(s)
- concept_is_in_subset
