Preferred Label : CAIX Inhibitor DTP348;
NCIt synonyms : 2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethylsulfamide;
NCIt related terms : DTP-348;
NCIt definition : An orally bioavailable, nitroimidazole-based sulfamide, carbonic anhydrase IX (CAIX)
inhibitor with potential antineoplastic activity. Upon administration, CAIX inhibitor
DTP348 inhibits tumor-associated CAIX, a hypoxia-inducible transmembrane glycoprotein
that catalyzes the reversible reaction and rapid interconversion of carbon dioxide
and water to carbonic acid, protons, and bicarbonate ions. This prevents the acidification
of the tumor's extracellular microenvironment and decreases the intracellular pH.
This results in increased cell death in CAIX-expressing, hypoxic tumors. In addition,
DTP348, through its nitroimidazole moiety, is able to sensitize hypoxic tumor cells
to irradiation. CAIX is overexpressed in various tumors and plays a key role in intra-
and extracellular pH regulation, cancer cell progression, survival, migration and
invasion.;
UNII : 2HB46A9CNM;
CAS number : 1383370-92-0;
Molecule name : DTP348;
NCI Metathesaurus CUI : CL474126;
Origin ID : C117731;
UMLS CUI : C3896869;
Semantic type(s)
- concept_is_in_subset
- has_target
