CAIX Inhibitor SLC-0111

Preferred Label : CAIX Inhibitor SLC-0111;

NCIt related terms : SLC-0111;

NCIt definition : A sulfonamide carbonic anhydrase inhibitor with potential antineoplastic activity. Upon administration, CAIX inhibitor SLC-0111 inhibits tumor-associated carbonic anhydrase IX (CAIX), an hypoxia-inducible transmembrane glycoprotein that catalyzes the reversible reaction and rapid interconversion of carbon dioxide and water to carbonic acid, protons, and bicarbonate ions. This prevents both the acidification of the tumor's extracellular microenvironment and cytoplasmic alkalization. This increases cell death in CAIX-expressing, hypoxic tumors. CAIX is overexpressed in various tumors and plays a key role in intra- and extracellular pH regulation, cancer cell progression, survival, migration and invasion; it is also involved in resistance to both chemo- and radiotherapy.;

UNII : ANM9DBL9JT;

CAS number : 178606-66-1;

Molecule name : SLC-0111; U-104;

NCI Metathesaurus CUI : CL474123;

NSC code : 213841;

Details

Origin ID

C117728;

UMLS CUI

C3896766;

Currated CISMeF NLP mapping
- SLC-0111 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SLC-0111 [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Carbonic Anhydrase 9 [NCIt concept]

Keyword's position in hierarchy(ies) :

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