Preferred Label : Autologous HNSCC DNA-transfected Semi-allogeneic Fibroblasts MRC-5 Vaccine;
NCIt definition : A vaccine consisting of lethally irradiated human fetal lung fibroblasts (Medical
Research Council 5 or MRC-5) transfected with autologous tumor DNA derived from a
head and neck squamous cell carcinoma (HNSCC), with potential immunostimulatory and
antineoplastic activities. Upon intradermal administration, the autologous HNSCC DNA-transfected
semi-allogeneic fibroblasts MRC-5 vaccine expresses HNSCC tumor-associated antigens
(TAAs), which may activate the immune system to induce a cytotoxic T-lymphocyte (CTL)
response against HNSCC cells. The MRC-5 cell line, established in 1966, is a human
diploid lung fibroblast cell line derived from the human lung tissue of a 14-week-old
male fetus.;
NCI Metathesaurus CUI : CL474120;
Origin ID : C117725;
UMLS CUI : C3899999;
Semantic type(s)
- concept_is_in_subset
