Preferred Label : NY-ESO-1-specific CD4-positive T Lymphocytes;
NCIt synonyms : CD4 NY-ESO-1-specific T Cells;
NCIt definition : A preparation of autologous CD4 T-lymphocytes sensitized to cancer-testis antigen
NY-ESO-1, with potential immunostimulating and antineoplastic activities. CD4-positive
T-lymphocytes are exposed to a NY-ESO-1 peptide ex vivo, expanded, and introduced
into the patient. The NY-ESO-1-specific CD4-positive T-lymphocytes may stimulate the
host immune system to produce a cytotoxic T-lymphocyte (CTL) response against tumor
cells expressing the NY-ESO-1 antigen, which results in tumor cell lysis. NY-ESO-1,
an antigen found in normal testis, may be upregulated in various cancers.;
NCI Metathesaurus CUI : CL474119;
Origin ID : C117724;
UMLS CUI : C3898190;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
