Preferred Label : Oltipraz;
NCIt synonyms : 3H-1,2-Dithiole-3-thione,4-methyl-5-pyrazinyl; 4-Methyl-5-(pyrazinyl)-3H-1,2-dithiole-3-thione; 5-[2-Pyrazinyl]-4-methyl-1,2-3-thione; 5-(2-Pyrazinyl)-4-methyl-1,2-dithiol-3-thione; 4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione; RP-35,972;
NCIt related terms : 3H-1,2-Dithiole-3-thione, 4-methyl-5-pyrazinyl-;
NCIt definition : A synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties.
Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase
(GST) and NAD(P)H:quinone oxidoreductase 1 (NQO1). The induction of detoxification
enzymes enhances the detoxification of certain cancer-causing agents, thereby enhancing
their elimination and preventing carcinogen-induced DNA damages. Although the exact
mechanism through which the anti-angiogenesis effect remains to be fully elucidated,
oltipraz maybe able to modulate the expression of a number of angiogenic factors,
thereby blocking the sustained and focal neovascularization in multiple tumor cell
types.;
Alternative definition : NCI-GLOSS: A drug used in cancer prevention.;
UNII : 6N510JUL1Y;
InChIKey : CKNAQFVBEHDJQV-UHFFFAOYSA-N;
CAS number : 64224-21-1;
Chemical formula : C8H6N2S3;
NSC code : 347901;
Codes from synonyms : NSC0347901; 00071; CDR0000045406;
Origin ID : C1177;
UMLS CUI : C0069456;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
