NCIt definition : A radioconjugate and cationic lipophilic agent consisting of fluorobenzyl triphenyl
phosphonium (FBnTP), labeled with the radioisotope fluorine F 18, with potential use
as a tracer for both mitochondrial membrane potential (MMP) and apoptosis, and as
a tumor imaging agent using positron emission tomography (PET). Upon administration,
fluorine F 18 FBnTP is taken up by cells and its uptake and accumulation within mitochondria
is directly correlated with MMP. Apoptosis causes a loss of membrane potential across
the inner mitochondrial membrane which decreases FBnTP mitochondrial uptake. As apoptosis
is suppressed in tumor cells, the FBnTP uptake is increased as compared to normal
cells. This allows, upon PET, for the imaging of cancer cells. As apoptotic-inducing
chemotherapeutic agents cause a collapse of MMP, this agent can also be used to assess
the response of tumor cells to those chemotherapeutic agents.;
Currated CISMeF NLP mapping