Boceprevir - CISMeF

Preferred Label : Boceprevir;

NCIt synonyms : 3-Azabicyclo(3.1.0)hexane-2-carboxamide, N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-((2S)-2-((((1,1- dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6- dimethyl-, (1R,2S,5S)-;

NCIt definition : An orally bioavailable, synthetic tripeptide inhibitor of the nonstructural protein 3 and 4A complex (NS3/NS4A), with potential activity against hepatitis C virus (HCV) genotype 1. Upon administration, boceprevir reversibly binds to the active center of the HCV NS3/NS4A and prevents NS3/NS4A protease-mediated polyprotein maturation. This disrupts the processing of viral proteins and the formation of a viral replication complex, which inhibits viral replication in HCV genotrype 1-infected host cells. NS3, a serine protease, is essential for the proteolytic cleavages within the HCV polyprotein and plays a key role during HCV viral RNA replication. NS4A is an activating factor for NS3. HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family.;

UNII : 89BT58KELH;

InChIKey : LHHCSNFAOIFYRV-DOVBMPENSA-N;

CAS number : 394730-60-0;

Drug name : Victrelis;

Molecule name : SCH 503034; EBP 520;

Details

Origin ID

C117292;

UMLS CUI

C1738934;

Automatic exact mappings (from CISMeF team)
- Product containing boceprevir (medicinal product) [SNOMED CT concept]
Currated CISMeF NLP mapping
- Boceprevir [LOINC component]
- Boceprevir [ICD-11 Extension code]
- Boceprevir [SMS substance]
- Boceprevir (substance) [SNOMED CT concept]
- N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide [MeSH Supplementary Concept]
- N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide [MeSH concept]
- boceprevir [International Nonproprietary Name]
- boceprevir [Substance BNPC]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Boceprevir [LOINC component]
- Boceprevir (substance) [SNOMED CT concept]
- N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide [MeSH Supplementary Concept]
- N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide [MeSH concept]
- Product containing boceprevir (medicinal product) [SNOMED CT concept]
- boceprevir [International Nonproprietary Name]
- boceprevir [ATC Code]
Validated automatic mappings to BTNT
- boceprevir [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- Hepatitis C Virus [NCIt concept]

Keyword's position in hierarchy(ies) :

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