Preferred Label : mTORC1/mTORC2/DHFR Inhibitor ABTL0812;
NCIt synonyms : 9,12-Octadecadienoic Acid, 2-Hydroxy-, (9Z,12Z)-;
NCIt related terms : ABTL-0812;
NCIt definition : An orally bioavailable, lipid analogue and inhibitor of raptor-mammalian target of
rapamycin (mTOR) (mTOR complex 1; mTORC1), rictor-mTOR (mTOR complex 2; mTORC2) and
dihydrofolate reductase (DHFR) with potential antineoplastic activity. Upon oral administration,
mTORC1/mTORC2/DHFR inhibitor ABTL0812 binds to and inhibits both mTORC1 and mTORC2,
which may result in apoptosis and a decrease in proliferation in mTORC1/2-expressing
tumor cells. mTOR is a serine/threonine kinase that is upregulated in some tumors;
it plays an important role in the PI3K/Akt/mTOR signaling pathway which is often deregulated
in cancer cells. In addition, ABTL0812 inhibits DHFR, an enzyme that reduces dihydrofolic
acid to tetrahydrofolic acid, thereby blocking tetrahydrofolate synthesis, and resulting
in both the depletion of nucleotide precursors and the inhibition of DNA, RNA and
protein synthesis. This induces autophagy-induced cell death and further inhibition
of cell proliferation.;
UNII : 0DE74TJ7EZ;
CAS number : 57818-44-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 57818-44-7
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G-SRS /a ;
Molecule name : ABTL0812;
NCI Metathesaurus CUI : CL474116;
Origin ID : C117290;
UMLS CUI : C3896929;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
