Preferred Label : Alpha-tocopheryloxyacetic Acid;
NCIt synonyms : 2,5,7,8-Tetramethyl-(2R-(4R,8R,12-trimethyltridecyl) chroman-6-yloxy) Acetic Acid; alpha-TEA; a-TEA;
NCIt related terms : .ALPHA.-TOCOPHERYLOXYACETIC ACID;
NCIt definition : An orally bioavailable vitamin E derivative with potential antineoplastic and immunostimulating
activities. Upon administration, alpha-tocopheryloxyacetic acid (alpha-TEA) induces
tumor autophagy; the autophagosomes formed, which carry tumor associated antigens
(TAAs), allow for increased cross-presentation of TAAs by professional antigen-presenting
cells (APCs). This activates a T cell-mediated T helper type 1 (TH1) response, generates
a cytotoxic T-lymphocyte (CTL) response against cancer cells, and reduces the frequency
of regulatory T-cell (Treg) differentiation. In addition, alpha-TEA modulates the
release of various cytokines and chemokines and induces tumor cell apoptosis. Altogether,
this results in decreased tumor cell proliferation.;
UNII : JW7FJR3ZLY;
CAS number : 261929-52-6;
Origin ID : C117234;
UMLS CUI : C1455006;
Currated CISMeF NLP mapping
- False automatic mappings
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
