Preferred Label : CD28CAR/CD137CAR-expressing T-Lymphocytes;
NCIt definition : Third generation, chimeric antigen receptor (CAR) cells composed of T-lymphocytes
transduced with a lentiviral vector expressing a CAR consisting of an a single chain
variable fragment specific for a particular antigen, coupled to the two co-stimulatory
signaling domains Cluster of Differentiation 28 (CD28) and Cluster of Differentiation
137 (CD137; 4-1BB), and the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3-zeta),
with potential immunomodulating and antineoplastic activities. Upon transfusion, CD28CAR/CD137CAR-expressing
T-lymphocytes are directed to, and induce selective toxicity in tumor cells expressing
the particular antigen. CD28, a T-cell surface-associated co-stimulatory molecule,
is required for T-cell activation, proliferation, and survival. The 4-1BB co-stimulatory
molecule signaling domain enhances activation and signaling after recognition of the
antigen. Furthermore, inclusion of the 4-1BB signaling domain may increase the antitumor
activity when compared to the inclusion of the CD28 co-stimulatory domain and CD3-zeta
alone.;
NCI Metathesaurus CUI : CL474100;
Origin ID : C117232;
UMLS CUI : C3899816;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
