Tusamitamab Ravtansine

Preferred Label : Tusamitamab Ravtansine;

NCIt synonyms : ADC SAR408701; Anti-CEACAM5 Antibody-Drug Conjugate SAR408701;

NCIt definition : An immunoconjugate consisting of anti-carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) conjugated to a cytotoxic agent, with potential antineoplastic activity. Upon administration of tusamitamab ravtansine the antibody moiety targets CEACAM5 on tumor cells. Upon antibody/antigen binding and internalization, the immunoconjugate releases the cytotoxic agent, which results in tumor cell death. CEACAM5, a member of the CEA family of proteins that plays a key role in cell migration, cell invasion, and cell adhesion, is overexpressed by a variety of cancer cell types.;

UNII : DSS3BE2ZXN;

CAS number : 2254086-60-5;

Molecule name : SAR408701;

NCI Metathesaurus CUI : CL474097;

Details

Origin ID

C117229;

UMLS CUI

C5446289;

Currated CISMeF NLP mapping
- tusamitamab ravtansine [MeSH Supplementary Concept]
- tusamitamab ravtansine [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- tusamitamab ravtansine [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 [NCIt concept]

Keyword's position in hierarchy(ies) :

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