NCIt definition : A synthetic cannabinoid and dibenzopyrane derivative with anti-emetic activity. Although
the mechanism of action has not been fully elucidated yet, it has been suggested that
nabilone is a highly selective and strong agonist for the cannabinoid receptors CB1
and CB2, both of which are coupled to Gi/o proteins. The CB1 receptors are expressed
predominantly in central and peripheral neurons and receptor stimulation has been
implicated in the reduction of chemotherapy-induced nausea.;