Preferred Label : Miltefosine;
NCIt synonyms : Choline Phosphate Hexadecyl Ester, Hydroxide, Inner Salt; Miltefosinum; 2-[[(Hexadecycloxy)hydroxyphosphinyl]oxy]-N,N,N-trimethylethanaminium Inner Salt; Miltefosina; Miltefosin; Hexadecylphosphocholine; n-Hexadecylphosphorylcholine; Hexadecyl 2-(N,N,N-trimethylamino)ethyl Phosphate;
NCIt definition : An orally- and topically-active alkyl-phosphocholine compound with potential antineoplastic
activity. Miltefosine targets cellular membranes, modulating cell membrane permeability,
membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction,
resulting in cell differentiation and inhibition of cell growth. This agent also inhibits
the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the
balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK)
pathways, thereby inducing apoptosis. As an immunomodulator, miltefosine stimulates
T-cells, macrophages and the expression of interleukin 3 (IL-3), granulocyte-macrophage
colony stimulating factor (GM-CSF), and interferon gamma (INF-gamma). (NCI04);
UNII : 53EY29W7EC;
InChIKey : PQLXHQMOHUQAKB-UHFFFAOYSA-N;
CAS number : 58066-85-6;
Drug name : Miltex;
Molecule name : D-18506;
Chemical formula : C21H46NO4P;
Codes from synonyms : 20314;
Origin ID : C1170;
UMLS CUI : C0068006;
CISMeF manual mappings
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
