Preferred Label : FOXP3 Treg-Specific Demethylated Region;
NCIt synonyms : FOXP3 TSDR; FOXP3 Treg Specific Demethylated Region;
NCIt definition : A genetic marker that distinguishes regulatory T-cells (Tregs) from other T-lymphocytes.
This marker is comprised of a demethylated CpG motif that is within the 5' untranslated
region of the FOXP3 gene, which is only found in Tregs. This CpG motif is methylated
in other T-cell lineages. The methylation status of this region of the FOXP3 gene
may influence the expression of the transcription factor, forkhead box protein P3.;
PubMed : 17298177;
Origin ID : C116968;
UMLS CUI : C3899163;
Semantic type(s)
- concept_is_in_subset
- related_to_genetic_biomarker
