Preferred Label : Sustained-release Lipid Inhaled Cisplatin;
NCIt synonyms : Sustained-release Lipid Inhalation Targeting Cisplatin; SR Inhaled Lipid Cisplatin;
NCIt definition : A sustained-release formulation for inhalation in which the inorganic platinum (Pt)
agent cisplatin is encapsulated in lipids, with potential antineoplastic activity.
Upon inhalation of the sustained-release lipid inhalation targeting (SLIT) cisplatin
into the lungs, this agent forms highly reactive, positively charged, Pt complexes,
which covalently bind to nucleophilic groups in DNA, preferably at the N7 position
of guanine bases. Pt complex binding introduces intrastrand and interstrand DNA cross-links,
and DNA-Pt-protein cross-links. These cross-links result in apoptosis and cell growth
inhibition of lung cancer cells. Encasement in liposomes prolongs cisplatin's efficacy
when compared to intravenously administered cisplatin; inhalation of cisplatin improves
its concentration at tumor sites in the lungs while minimizing its systemic toxicity.;
Drug name : SLIT Cisplatin;
Origin ID : C116884;
UMLS CUI : C1541510;
Semantic type(s)
- concept_is_in_subset
