Preferred Label : Simotaxel;
NCIt synonyms : 5Beta,20-epoxy-1,2alpa,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one-4-acetate
2-benzoate Ester with (2R,3S)-N-Isopropoxycarbonyl-3-(2-thienyl) Isoserine; Taxane-997;
NCIt definition : A semi-synthetic, orally bioavailable, third-generation taxane derivative and microtubule-stabilizing
agent, with potential antineoplastic activity. Upon administration, simotaxel binds
to tubulin, promotes microtubule assembly and stabilization, and prevents microtubule
depolymerization. This results in G2/M arrest, apoptosis and the inhibition of cell
proliferation in susceptible tumor cells. This agent is a poor substrate for P-glycoprotein-related
drug resistance mechanisms; therefore, it may be useful for treating multi-drug resistant
tumors. MST-997 is more potent than paclitaxel and docetaxel and overcomes paclitaxel
and docetaxel resistance in certain tumor cell types.;
UNII : E1M30YOE59;
InChIKey : SLGIWUWTSWJBQE-VLCCYYTCSA-N;
CAS number : 791635-59-1;
Molecule name : TL-909; MST-997;
Origin ID : C116871;
UMLS CUI : C4552101;
Currated CISMeF NLP mapping
- MST 997 [MeSH Supplementary Concept]
- Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
