Preferred Label : Pegylated Liposomal Nanoparticle-based Docetaxel Prodrug MNK-010;
NCIt synonyms : Pegylated Liposomal Docetaxel Prodrug MNK-010;
NCIt definition : A formulation containing pegylated liposomal nanoparticles encapsulating a prodrug
of the poorly water-soluble, second-generation taxane analog docetaxel, with potential
antineoplastic activity. Upon intravenous administration of the liposomal docetaxel
prodrug MNK-010, docetaxel is slowly released into the systemic circulation and accumulates
at the tumor site due to the unique characteristics of the tumor's vasculature. In
turn, docetaxel is taken up by tumor cells, and subsequently binds to and stabilizes
the beta-subunit of tubulin, thereby stabilizing microtubules and inhibiting microtubule
disassembly. This results in cell cycle arrest and induces cell death. Compared to
the administration of docetaxel alone, this formulation is able to increase the delivery
of docetaxel into tumors, thereby increasing docetaxel's efficacy while minimizing
its toxicity. In addition, this formulation solubilizes docetaxel without the use
of toxic solvents, thereby permitting the administration of larger doses of docetaxel
while avoiding solvent-associated toxicity.;
Molecule name : MP-3549-1; MNK-010;
NCI Metathesaurus CUI : CL471764;
Origin ID : C116869;
UMLS CUI : C4053616;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
