Preferred Label : Recombinant Human Apolipoprotein(a) Kringle V MG1102;
NCIt synonyms : Recombinant Human Apo (a) Kringle V MG1102;
NCIt definition : An 86 amino-acid long polypeptide fragment of a recombinant form of human apolipoprotein
(a) (apo(a)) kringle V, with potential anti-angiogenic and antineoplastic activities.
Although the exact mechanism of action has yet to be fully elucidated, upon administration,
recombinant human apo(a) kringle V MG1102 inhibits the fibronectin-mediated migration
of endothelial cells, binds to and blocks the activity of alpha 3 beta 1 integrin
(a3b1 integrin), inhibits the activation of focal adhesion kinase (FAK) and FAK-mediated
signaling, and leads to the inhibition of the p130 Crk-associated substrate (p130CAS)-c-Jun
NH2-terminal kinase (JNK) pathway. This inhibits tumor angiogenesis, induces mitochondrial-mediated
apoptosis of tumor cells and tumor-associated endothelial cells, and suppresses tumor
growth and metastasis. Apo(a), a glycoprotein component of human lipoprotein(a), contains
repeated kringle domains; certain kringle domains of apo(a), including the plasminogen
kringle V homolog (KV), have anti-angiogenic effects.;
Molecule name : MG1102;
NCI Metathesaurus CUI : CL433737;
Origin ID : C116864;
UMLS CUI : C3896813;
Semantic type(s)
- concept_is_in_subset
