Preferred Label : Hyperpolarized Carbon C 13 Pyruvate;
NCIt synonyms : Hyperpolarized 13C-Pyruvate; Hyperpolarized Pyruvate (13C);
NCIt definition : A hyperpolarized pyruvate labeled with carbon C 13, with potential usage in the diagnostic
imaging of cancer cells. Upon administration, carbon C 13 hyperpolarized pyruvate
(13C-pyruvate) is taken up by cancer cells and is further metabolized to lactate and
alanine for use in glycolysis, lipogenesis and protein synthesis, to support the enhanced
metabolic needs of tumor cells. As tumor cells are rapidly proliferating, their uptake
of pyruvate and its subsequent conversion to alanine and lactate are higher than non-proliferating
cells. Upon nuclear magnetic resonance (NMR)-based imaging (MRI), both hyperpolarized
13C-pyruvate as well as its metabolites can be detected and visualized in cancer cells;
this may aid in the diagnosis of cancer. Hyperpolarization of 13C-pyruvate, using
dynamic nuclear polarization (DNP), enhances NMR signals.;
NCI Metathesaurus CUI : CL433740;
Origin ID : C116853;
UMLS CUI : C3898831;
Semantic type(s)
concept_is_in_subset