Preferred Label : Diethylnorspermine;
NCIt synonyms : N1,N11-bis(ethyl)norspermine; N(1),N(11)-diethylnorspermine; DENSPM; N 1 N 11 bis ethyl norspermine;
NCIt definition : A synthetic bis-ethyl analogue of spermine with potential antineoplastic activity.
N(1),N(11)-bis(ethyl)norspermine (DENSPM), a N-terminally alkylated tetraamine and
polyamine mimetics, disrupts polyamine pool homeostasis by modulating the activities
of the biosynthetic enzymes, ornithine decarboxylase (ODC), and S-adenosylmethionine
decarboxylase (AdoMetDC). This agent also reduces polyamine concentrations through
the induction of the catabolic enzyme spermidine/spermine N1-acetyltransferase 1 (SSAT).
Polyamines, an integral part of the DNA helix structure, play a critical role in cell
division, differentiation and membrane function. Disruption of normal polyamine concentrations
by DENSPM may lead to cell growth inhibition.;
UNII : HLI827Z1ST;
CAS number : 121749-39-1;
Molecule name : CI-1006;
Origin ID : C1168;
UMLS CUI : C5779584;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
