Preferred Label : Carbon C 11 Sepantronium Bromide;
NCIt synonyms : 11C-YM155;
NCIt definition : A radiotracer composed of the bromide salt form of sepantronium, a small-molecule
survivin antagonist and proapoptotic agent, labeled with the radionuclide carbon C
11, with potential positron emission tomography (PET) imaging activity. Upon administration,
sepantronium is selectively taken up by tumor cells, binds to the survivin promoter
and inhibits the transcription of survivin, which results in decreased survivin expression.
Upon PET imaging, the tissue distribution of sepantronium and its tumor uptake can
be assessed. Survivin, a member of the inhibitor of apoptosis (IAP) gene family, is
overexpressed in a variety of human cancers; its expression in tumors is associated
with a more aggressive phenotype, increased cancer cell proliferation, shorter survival
times, and a decreased response to chemotherapy.;
NCI Metathesaurus CUI : CL473937;
Origin ID : C116790;
UMLS CUI : C3899709;
Semantic type(s)
- concept_is_in_subset
