" /> Ianalumab - CISMeF





Preferred Label : Ianalumab;

NCIt synonyms : HuCAL-based Antibody VAY736; Human Combinatorial Antibody Library-based Monoclonal Antibody VAY736;

NCIt definition : A fully human combinatorial antibody library (HuCAL)-derived monoclonal antibody targeting the B-cell-activating factor receptor (BAFF-R), with potential anti-inflammatory and antineoplastic activities. Upon administration, ianalumab targets and binds to BAFF-R, which inhibits both BAFF/BAFF-R interaction and BAFF-R-mediated signaling. This may decrease cell growth in tumor cells expressing BAFF-R. BAFF-R, also known as tumor necrosis factor receptor superfamily member 13C, is overexpressed in certain tumor cell types and autoimmune diseases. In cancer cells, BAFF-R plays a key role in B-cell proliferation and survival. VAY736 was developed using HuCAL technology.;

UNII : ZN2GQ3II96;

CAS number : 1929549-92-7;

Molecule name : VAY736; VAY 736;

NCI Metathesaurus CUI : CL473936;

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09/05/2025


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