Preferred Label : Lifastuzumab Vedotin;
NCIt synonyms : ADC DNIB0600A;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the sodium-dependent phosphate transport protein 2B (NaPi2b), and covalently linked
to monomethyl auristatin E (MMAE), an auristatin derivative and a potent microtubule
disrupting agent, with potential antineoplastic activity. Upon administration, the
monoclonal antibody moiety of DNIB0600A binds to NaPi2b-expressing tumor cells and
is internalized, thereby delivering MMAE intracellularly. Proteolytic cleavage releases
MMAE, which then binds to tubulin and inhibits its polymerization, resulting in G2/M
phase arrest and tumor cell apoptosis. NaPi2b, a tumor-associated antigen (TAA), overexpressed
in a variety of cancer cell types, plays a key role in transport of inorganic phosphate
and the maintenance of phosphate homeostasis.;
UNII : 7IUT83FK6S;
CAS number : 1401812-88-1;
Molecule name : RG-7599; DNIB0600A;
NCI Metathesaurus CUI : CL433844;
Origin ID : C116747;
UMLS CUI : C4682400;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
